that depends on a number of things like:
what language is the program made in?
what dependencies does the program have?
etc...
in this case I'm assuming it's a vb.net program that doesn't any dependencies outside the .Net framework in which case all you need to do is figure out if there's an equivalent of the .Net framework for the mac.
If it's a Java program, there is a JVM for the Mac already.
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